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| S. No. | Chemical Structure | Product Name | CAS No. | Therapeutic Category |
|---|---|---|---|---|
| 1 |  |
Palbociclib | 571190-30-2 | Oncology |
| 2 |  |
Crizotinib | 877399-52-5 | Oncology |
| 3 |  |
Tofacitinib | 477600-75-2 | Immunology |
| 4 |  |
Rimegepant | 1289023-67-1 | Migraine / CNS |
| 5 |  |
Ritlecitinib | 1792180-81-4 | Immunology |
| 6 |  |
Osivelotor | 2417955-18-9 | Hematology |
| 7 |  |
Talazoparib | 1207456-01-6 | Oncology |
| 8 |  |
Ertugliflozin | 1210344-57-2 | Diabetes / Metabolic |
| 9 |  |
Apixaban | 503612-47-3 | Cardiovascular / Anticoagulant |
| 10 |  |
Linezolid | 165800-03-3 | Anti-infective |
| 11 |  |
Sildenafil | 139755-83-2 | Urology / Cardiovascular |
| S. No. | Intermediate Name | CAS No. | Target API |
|---|---|---|---|
| 1 | 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one | 1016636-76-2 | Palbociclib |
| 2 | tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate | 571188-59-5 | Palbociclib |
| 3 | (3R,6S)-1-Benzyl-6-methylpiperidin-3-amine | 2295746-50-6 | Ritlecitinib |
| 4 | 4,6-Dichloro-1H-indole | 101495-18-5 | Crizotinib |
| 5 | 7,8-Dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione | 39713-40-1 | Rimegepant |
| 6 | 1-(1-(1H-Imidazole-1-carbonyl)piperidine-4-carbonyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one | 1373116-06-3 | Rimegepant |
| 7 | Pyridine-2,3-diamine | 452-58-4 | Rimegepant |
| 8 | 1-Methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrile hydrochloride | 1643141-20-1 | Lorlatinib |
| 9 | (S)-5-Fluoro-3-methylisobenzofuran-1(3H)-one | 1803573-19-4 | Lorlatinib |
| 10 | 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine | 90213-66-4 | Tofacitinib |
| S. No. | Regulatory Starting Material (RSMs) Name | CAS No. |
|---|---|---|
| 1 | butyl 2,2-dimethylcyclopropane-1-carboxylate | 71740-06-2 |
| 2 | 2-hydrazinylethan-1-ol | 109-84-2 |
| 3 | 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine | 90213-66-4 |
| 4 | (3,4-dichlorophenyl)hydrazine | 13124-18-0 |
| 5 | 2,6-difluoro-3,5-dimethoxyaniline | 651734-54-2 |
| 6 | 4-iodo-1-methyl-1H-pyrazole-5-carbonitrile | 1354705-14-8 |
| 7 | 2,5-dichloro-3,6-dimethylpyrazine | 27023-19-4 |
| 8 | 6-chloro-2-fluoro-7H-purine | 1651-29-2 |
| 9 | 5-((3-ethoxypyridin-2-yl)oxy) nicotinonitrile | 2639372-96-4 |
| 10 | 4-(4,6-dimorpholino-1,3,5-triazin-2-yl)cyclohexan-1-amine | 1197159-91-3 |
| 11 | (7R,7aS)-7-ethyl-3,3-dimethyltetrahydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one | 1817631-47-2 |
| 12 | diethyl 2,2'-(1,3-phenylene)diacetate | 36076-20-7 |
| 13 | N-((6S)-6-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | 2042650-70-2 |
| 14 | methyl (1S,3R,4R,5R)-3-acetoxy-4,5-dihydroxycyclohexane-1-carboxylate | 1104200-21-6 |
| 15 | methyl (E)-6-fluoro-3-(2-nitrovinyl)-1H-indole-4-carboxylate | 2101705-87-5 |
| 16 | 3-fluoropropane-1-sulfonyl chloride | 461-28-9 |
| 17 | tert-butyl (2-chloro-4-fluoro-3-iodophenyl)carbamate | 2573784-38-8 |
| 18 | 2-amino-6-fluoroquinolin-3-ol | 2435612-57-8 |
| 19 | 6-(difluoromethyl)-8-((2R)-2-hydroxy-2-methylcyclopentyl)-2-((4-(methylsulfonyl)cyclohexyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one | 2185857-97-8 |
| 20 | 6-amino-3,5-dimethyl-4a,8adihydroquinazolin-4(3H)-one | 2573783-01-2 |
| 21 | (R)-3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanoic acid | 1215198-45-0 |
| 22 | N-((3R,4R)-4-fluoropyrrolidin-3-yl)-3-(methylsulfonyl)propanamide | 1776113-95-1 |
| 23 | (1R,2S)-1-((3,6-diethylpyrazin-2-yl)amino)-2,3-dihydro-1H-inden-2-ol | 535934-27-1 |
| 24 | 3-(methoxymethyl)-1-methyl-1H-pyrazole-5-carboxylic acid | 1783796-51-9 |
| 25 | 6-bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one | 1016636-76-2 |
| 26 | 1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-amine | 865774-26-1 |
| 27 | 1-methyl-1H-pyrazol-4-amine | 69843-13-6 |
| 28 | 1-chloro-7-methoxy-1,2-dihydroisoquinoline-6-carbonitrile | 1427393-40-5 |
| 29 | 4-(tert-butyl)-2-nitroaniline | 6310-19-6 |
| 30 | ethyl 4-iodo-1-methyl-1H-pyrazole-5-carboxylate | 1354705-42-2 |
| 31 | (3R,4R,5S)-3,4,5-tris(benzyloxy)-2-methyl-6-(p-tolylthio)tetrahydro-2H-pyran | 807361-40-6 |
| 32 | Sodium chlorodifluoromethanesulfinate | 772339-78-3 |
| 33 | (S)-4-(1-benzylpyrrolidin-2-yl)-3-methoxy-1-methyl-1H-pyrazole | 2227384-88-3 |
| 34 | 4-chloro-2-iodoaniline | 63069-48-7 |
| 35 | 1-cyclopropylbutane-1,3-dione | 21573-10-4 |
| 36 | 5-bromo-2-hydrazinylpyridine | 77992-44-0 |
| 37 | 1-methyl-4-nitro-3-propyl-1H-pyrazole-5-carboxamide | 139756-01-7 |
| 38 | 4-(5-amino-3-(tert-butyl)-1H-pyrazol-1-yl)-2-chlorophenol | 945994-86-5 |
| 39 | 2-((2-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)phenyl)thio)ethan-1-ol | 1178560-66-1 |
| 40 | 2-methylbenzo[d]isothiazol-3(2H)-one | 2527-66-4 |
| 41 | 6-((1H-pyrazol-1-yl)methyl)-4-methoxybenzo[d]isoxazol-3-amine | 2568912-43-4 |
| 42 | methyl (R)-2-(chloromethyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxylate | 2436737-09-4 |
| 43 | 6-((1H-pyrazol-1-yl)methyl)-4-methoxybenzo[d]isoxazol-3-amine | 2568912-43-4 |
| 44 | 4-bromo-2,6-difluoroaniline | 67567-26-4 |
| 45 | octanedioic acid | 505-48-6 |
| 46 | oxetane-2-carbonitrile | 56372-90-8 |
| 47 | (1r,3r)-3-(cyanomethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)cyclobutane-1-carbonitrile | 2127110-50-1 |
| 48 | 6'-fluorospiro[cyclopropane-1,3'-indolin]-2'-one | 1378834-16-2 |
| 49 | 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile | 380843-75-4 |
| 50 | methyl (R)-2-(chloromethyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylate | 2436737-09-4 |
| 51 | 3-fluoro-4-(((6-(piperidin-4-yl)pyridin-2-yl)oxy)methyl)benzonitrile | 2230200-24-3 |
| 52 | 6-amino-5-chloro-3-methyl-4a,8adihydroquinazolin-4(3H)-one | 2754409-55-5 |
| 53 | 6-chloroindolin-2-one | 56341-37-8 |
| 54 | N-(2-chloro-3-((5-chloro-3-methyl-4-oxo-3,4,4a,8a-tetrahydroquinazolin-6-yl)amino)-4-fluorophenyl)-3-fluoroazetidine-1-sulfonamide | 2754408-94-9 |
| 55 | ((4aS,5aR)-5a-methyl-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indazol-3-yl)methanol | 2790519-38-7 |
| S. No. | Material Name | CAS No. |
|---|---|---|
| 1 | Boc-Asp(OtBu)-OH | 1676-90-0 |
| 2 | H-Ile-OBzl.Ts | 16652-75-8 |
| 3 | Boc-Ile-OH | 13139-16-7 |
| 4 | H-Ala-OBzl.HCl | 5557-83-5 |
| 5 | Fmoc-Asp(OtBu)-OH | 71989-14-5 |
| 6 | H-Glu(OtBu)-OH | 2419-56-7 |
| 7 | H-Pro-Obzl. HCl | 16652-71-4 |
| 8 | Z-Leu-OH | 2018-66-8 |
| 9 | H-Thr(tBu)-OtBu | 5854-78-4 |